A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction

2006611 citationsJournal Articlebronze Open Access

Authors

Toby Freyman · Boston Scientific (United States)

Glenn M. Polin · Hospital of the University of Pennsylvania

Hashim Osman · Hospital of the University of Pennsylvania

Jody Crary · Boston Scientific (United States)

Minmin Lü · Hospital of the University of Pennsylvania

Lan Cheng · Hospital of the University of Pennsylvania

Maria Palasis

Abstract

IC and EC injection of MSCs post-MI resulted in increased engraftment within infarcted tissue when compared with IV infusion, and IC was more efficient than EC. However, IC delivery was also associated with a higher incidence of decreased coronary blood flow. EC delivery into acutely infarcted myocardial tissue was safe and well tolerated and was associated with decreased remote organ engraftment with compared with IC and IV deliveries.

Topics & Keywords

Mesenchymal stem cell research Electrospun Nanofibers in Biomedical Applications Tissue Engineering and Regenerative Medicine

Publication Details

Published in: European Heart Journal

Volume 27, Issue 9, pp. 1114-1122

DOI: 10.1093/eurheartj/ehi818

Field-Weighted Citation Impact: 14.87

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A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction

Authors

Abstract

Topics & Keywords

Publication Details