Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

2009187 citationsJournal Articlebronze Open Access

Authors

Yusuf Özlem İlbey · Bezmialem Foundation University Medical Faculty Hospital

Emin Özbek · Bezmialem Foundation University Medical Faculty Hospital

Mustafa Çekmen · Kocaeli Üniversitesi

Abdülmuttalip Şimşek · Bezmialem Foundation University Medical Faculty Hospital

Alper Ötünçtemur · Bezmialem Foundation University Medical Faculty Hospital

Adnan Somay · Bezmialem Foundation University Medical Faculty Hospital

Abstract

MAPK and NF-kB activation have a significant role in CIS-induced testicular toxicity. CMN has a strong potential for use as a therapeutic adjuvant in CIS gonadotoxicity.

Topics & Keywords

Chemotherapy-induced organ toxicity mitigation Sperm and Testicular Function Testicular diseases and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Human Reproduction

Volume 24, Issue 7, pp. 1717-1725

DOI: 10.1093/humrep/dep058

Field-Weighted Citation Impact: 7.14