Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice

2002452 citationsJournal Article

Authors

Aaron D. Tward · University of California System

Yu-Rong Xia · University of California System

Xuping Wang · University of California System

Yi-Shou Shi · University of California System

Christina Park · University of California System

Lawrence W. Castellani · University of California System

Aldons J. Lusis

Abstract

Our results indicate that PON1 protects against atherosclerosis in a dose-dependent manner and suggest that it may be a potential target for developing therapeutic agents for the treatment of cardiovascular disease.

Topics & Keywords

Paraoxonase enzyme and polymorphisms Cynara cardunculus studies Apelin-related biomedical research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 106, Issue 4, pp. 484-490

DOI: 10.1161/01.cir.0000023623.87083.4f

Field-Weighted Citation Impact: 13.54