Mast Cell–Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1

2005102 citationsJournal Articlebronze Open Access

Authors

Khalid Al‐Nedawi · Medical University of Lodz

Janusz Szemraj · Medical University of Lodz

Czesław S. Cierniewski · Medical University of Lodz

Abstract

It can be concluded that mast cell-derived exosomes via significant upregulation of PAI-1 secretion from endothelial cells may provide feedback between the characteristically increased PAI-1 levels and procoagulant states, both observed in diverse syndromes manifesting as endothelial cell dysfunction.

Topics & Keywords

Extracellular vesicles in disease Protease and Inhibitor Mechanisms Coagulation, Bradykinin, Polyphosphates, and Angioedema

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 25, Issue 8, pp. 1744-1749

DOI: 10.1161/01.atv.0000172007.86541.76

Field-Weighted Citation Impact: 1.48

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Mast Cell–Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1

Authors

Abstract

Topics & Keywords

Publication Details