Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY)

2014286 citationsJournal Articlebronze Open Access

Authors

Erik van Duijn · Leiden University

David Craufurd · University of Manchester

Anna A.M. Hubers · Leiden University Medical Center

Erik J. Giltay · Leiden University Medical Center

Raphael M. Bonelli · Sigmund Freud University Vienna

Hugh Rickards · Birmingham and Solihull Mental Health NHS Foundation Trust

Karen E. Anderson

Abstract

A variety of neuropsychiatric symptoms are highly prevalent in different stages of HD in this European HD population, with apathy as the most frequent symptom. Depression, irritability/aggression and OCBs are prevalent in all stages of HD. Apathy was the key neuropsychiatric symptom occurring most often in advanced HD stages. Due to possible selection of relatively healthy participants, prevalences reported in this study might be an underestimation of prevalence in the entire HD population.

Topics & Keywords

Genetic Neurodegenerative Diseases Neurological disorders and treatments Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neurology Neurosurgery & Psychiatry

Volume 85, Issue 12, pp. 1411-1418

DOI: 10.1136/jnnp-2013-307343

Field-Weighted Citation Impact: 6.76