Cytogenetic analysis of 531 Chinese women with premature ovarian failure

2012121 citationsJournal Articlebronze Open Access

Authors

Xue Jiao · Shandong University

Chunrong Qin · Shenzhen Maternity and Child Healthcare Hospital

J. Li · Sun Yat-sen University

Yingying Qin · Shandong University

Xuan Gao · Shandong University

Bing Zhang · Guangxi Maternal and Child Health Hospital

X. Zhen ·

Abstract

The overall prevalence of chromosomal abnormalities was 12.1% in this first large scale report of chromosomal aberrations in Chinese women with POF. In one of the largest samples of women with POF reported from any population, the prevalence of X-structural abnormalities, X-autosome translocations and X aneuploidy confirms the essential role X chromosomal abnormalities play in POF.

Topics & Keywords

Reproductive Biology and Fertility Prenatal Screening and Diagnostics Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Human Reproduction

Volume 27, Issue 7, pp. 2201-2207

DOI: 10.1093/humrep/des104

Field-Weighted Citation Impact: 7.55