Nanotheranostics: Congo Red/Rutin‐MNPs with Enhanced Magnetic Resonance Imaging and H<sub>2</sub>O<sub>2</sub>‐Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

2015151 citationsJournal Articlegreen Open Access

Authors

Bingbing Hu · Institute of Process Engineering

Fengying Dai · Beijing Academy of Science and Technology

Zhanming Fan · Beijing Anzhen Hospital

Guanghui Ma · Institute of Process Engineering

Qunwei Tang · Ocean University of China

Xin Zhang · Institute of Process Engineering

Abstract

As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.

Topics & Keywords

Advanced Nanomaterials in Catalysis Graphene and Nanomaterials Applications Nanoparticle-Based Drug Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Advanced Materials

Volume 27, Issue 37, pp. 5499-5505

DOI: 10.1002/adma.201502227

Field-Weighted Citation Impact: 4.46