A genome-wide association study of serum uric acid in African Americans

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Authors

Bashira A. Charles · National Human Genome Research Institute

Daniel Shriner · National Human Genome Research Institute

Ayo P. Doumatey · National Human Genome Research Institute

Guanjie Chen · National Human Genome Research Institute

Jie Zhou · National Human Genome Research Institute

Hanxia Huang · National Human Genome Research Institute

Alan Herbert

Abstract

The most strongly associated locus for SUAL in EA populations was also the most strongly associated locus in this AA sample. This finding provides evidence for the role of SLC2A9 in uric acid metabolism across human populations. Additionally, our findings demonstrate the utility of following-up EA populations GWAS signals in African-ancestry populations with weaker linkage disequilibrium.

Topics & Keywords

Gout, Hyperuricemia, Uric Acid Alcohol Consumption and Health Effects Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Medical Genomics

Volume 4, Issue 1, pp. 17-17

DOI: 10.1186/1755-8794-4-17

Field-Weighted Citation Impact: 6.19