Positron Emission Tomography Using [18F]Galacto-RGD Identifies the Level of Integrin αvβ3 Expression in Man

2006329 citationsJournal Articlebronze Open Access

Authors

Ambros J. Beer

Roland Haubner · Innsbruck Medical University

Mario Sarbia

Hans H. Goebel · Orthopedic One

Stephan Luderschmidt · University Dermatology

Anca-Ligia Grosu

Oliver Schnell · Ludwig-Maximilians-Universität München

Markus Niemeyer

Horst Kessler

Abstract

Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry. PET with [18F]Galacto-RGD might therefore be used as a new marker of angiogenesis and for individualized planning of therapeutic strategies with alpha(v)beta3-targeted drugs.

Topics & Keywords

Cell Adhesion Molecules Research HER2/EGFR in Cancer Research Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 12, Issue 13, pp. 3942-3949

DOI: 10.1158/1078-0432.ccr-06-0266

Field-Weighted Citation Impact: 13.02