Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

2012273 citationsJournal Article

Authors

Deryk Loo · MacroGenics (United States)

Ralph Alderson · MacroGenics (United States)

Francine Z. Chen · MacroGenics (United States)

Ling Huang · MacroGenics (United States)

Wenjun Zhang · MacroGenics (United States)

Sergey Gorlatov · MacroGenics (United States)

Steve Burke ·

Abstract

This data supports evaluation of MGA271 clinical utility in B7-H3-expressing cancer, while validating a combination of a nontarget biased approach of intact cell immunizations and immunohistochemistry to identify novel cancer antigens with Fc-based mAb engineering to enable potent antitumor activity.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Immunotherapy and Immune Responses CAR-T cell therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 18, Issue 14, pp. 3834-3845

DOI: 10.1158/1078-0432.ccr-12-0715

Field-Weighted Citation Impact: 7.52