Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

2014300 citationsJournal Articlebronze Open Access

Authors

Cristina Cunha

Franco Aversa · University of Parma

João F. Lacerda · University of Lisbon

Alessandro Busca · Gruppo Italiano per il Trapianto di Midollo Osseo

Oliver Kurzai · Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

Matthias Grube · University of Regensburg

Jürgen Löffler · Universitätsklinikum Würzburg

Abstract

Genetic deficiency of PTX3 affects the antifungal capacity of neutrophils and may contribute to the risk of invasive aspergillosis in patients treated with HSCT. (Funded by the European Society of Clinical Microbiology and Infectious Diseases and others.).

Topics & Keywords

Biomarkers in Disease Mechanisms Leptospirosis research and findings

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 370, Issue 5, pp. 421-432

DOI: 10.1056/nejmoa1211161

Field-Weighted Citation Impact: 14.66