Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout

20051,342 citationsJournal Articlebronze Open Access

Authors

Michael A. Becker · University of Chicago

H. Ralph Schumacher

Robert L. Wortmann · University of Tulsa

Abstract

Febuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Similar reductions in gout flares and tophus area occurred in all treatment groups.

Topics & Keywords

Gout, Hyperuricemia, Uric Acid Case Reports on Hematomas Hepatitis C virus research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 353, Issue 23, pp. 2450-2461

DOI: 10.1056/nejmoa050373

Field-Weighted Citation Impact: 21.01