Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

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Authors

Rakez Kayed · University of California, Irvine

Elizabeth Head · University of California, Irvine

Floyd Sarsoza · University of California, Irvine

Tommy Saing · University of California, Irvine

Carl W. Cotman · University of California, Irvine

Mihaela Necula · University of California, Irvine

Lawrence Margol

Abstract

Since the fibril specific antibodies are conformation dependent, sequence-independent, and recognize epitopes that are distinct from those present in prefibrillar oligomers, they may have broad utility for detecting and characterizing the accumulation of amyloid fibrils and fibrillar type oligomers in degenerative diseases.

Topics & Keywords

Alzheimer's disease research and treatments Amyloidosis: Diagnosis, Treatment, Outcomes Prion Diseases and Protein Misfolding

Publication Details

Published in: Molecular Neurodegeneration

Volume 2, Issue 1, pp. 18-18

DOI: 10.1186/1750-1326-2-18

Field-Weighted Citation Impact: 14.54

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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Authors

Abstract

Topics & Keywords

Publication Details