Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors

2005182 citationsJournal Article

Authors

Angelica Facoetti · University of Pavia

Rosanna Nano · University of Pavia

Paola Zelini · University of Pavia

Patrizia Morbini · Istituti di Ricovero e Cura a Carattere Scientifico

E. Benericetti · University of Parma

Mauro Ceroni · Fondazione Lanza

Michael Campoli ·

Abstract

The presence of HLA antigen defects in malignant brain tumors may provide an explanation for the relatively poor clinical response rates observed in the majority of the T cell-based immunotherapy clinical trials conducted to date in patients with malignant brain tumors.

Topics & Keywords

Immunotherapy and Immune Responses CAR-T cell therapy research Immune Cell Function and Interaction

Publication Details

Published in: Clinical Cancer Research

Volume 11, Issue 23, pp. 8304-8311

DOI: 10.1158/1078-0432.ccr-04-2588

Field-Weighted Citation Impact: 2.27

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Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors

Authors

Abstract

Topics & Keywords

Publication Details