Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers

2013555 citationsJournal Articlegreen Open Access

Authors

William R. Polkinghorn · UNC Lineberger Comprehensive Cancer Center

Joel S. Parker · UNC Lineberger Comprehensive Cancer Center

Man X. Lee · UNC Lineberger Comprehensive Cancer Center

Elizabeth M. Kass · UNC Lineberger Comprehensive Cancer Center

Daniel E. Spratt · Albert Einstein College of Medicine

Phillip J. Iaquinta · University of North Carolina at Chapel Hill

Vivek Arora

Abstract

We demonstrate that the AR regulates a network of DNA repair genes, providing a potential mechanism by which androgen deprivation synergizes with radiotherapy for prostate cancer.

Topics & Keywords

Prostate Cancer Treatment and Research Cancer, Lipids, and Metabolism Prostate Cancer Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Discovery

Volume 3, Issue 11, pp. 1245-1253

DOI: 10.1158/2159-8290.cd-13-0172

Field-Weighted Citation Impact: 17.53