The 11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

2010312 citationsJournal Articlebronze Open Access

Authors

Julio Rosenstock · Dallas Diabetes Research Center

Salomon Banarer · Dallas Diabetes Research Center

Vivian Fonseca · Tulane University

Silvio E. Inzucchi · Yale University

William Sun · Incyte (United States)

Wenqing Yao · Incyte (United States)

Gregory Hollis ·

Abstract

INCB13739 added to ongoing metformin therapy was efficacious and well tolerated in patients with type 2 diabetes who had inadequate glycemic control with metformin alone. 11BetaHSD1 inhibition offers a new potential approach to control glucose and cardiovascular risk factors in type 2 diabetes.

Topics & Keywords

Hormonal Regulation and Hypertension Apelin-related biomedical research Electrolyte and hormonal disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes Care

Volume 33, Issue 7, pp. 1516-1522

DOI: 10.2337/dc09-2315

Field-Weighted Citation Impact: 20.01