A Community-Based Multicenter Trial of Pharmacokinetically Guided 5-Fluorouracil Dosing for Personalized Colorectal Cancer Therapy

201443 citationsJournal Articlebronze Open Access

Authors

Jai N. Patel · Carolinas Healthcare System

Bert H. O’Neil · Indiana University – Purdue University Indianapolis

Allison M. Deal · University of North Carolina at Chapel Hill

Joseph G. Ibrahim · University of North Carolina at Chapel Hill

Gary B. Sherrill · Cone Health

Oludamilola Olajide · Rex Hospital

Prashanti Atluri

Abstract

PK-guided 5-FU dosing resulted in significantly fewer underdosed patients and less gastrointestinal toxicity and allows for the application of personalized colorectal cancer therapy in the community setting.

Topics & Keywords

Colorectal Cancer Treatments and Studies Cancer Treatment and Pharmacology Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Oncologist

Volume 19, Issue 9, pp. 959-965

DOI: 10.1634/theoncologist.2014-0132

Field-Weighted Citation Impact: 1.34