Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

2007582 citationsJournal Articlebronze Open Access

Authors

Tammie C. Yeh · Array BioPharma (United States)

Vivienne Marsh · Array BioPharma (United States)

Bryan A. Bernat · Array BioPharma (United States)

Josh Ballard · Array BioPharma (United States)

Heidi Colwell · Array BioPharma (United States)

R J Evans · Array BioPharma (United States)

Janet Parry

Abstract

ARRY-142886 is a potent and selective MEK1/2 inhibitor that is highly active in both in vitro and in vivo tumor models. This compound is currently being investigated in clinical studies.

Topics & Keywords

Melanoma and MAPK Pathways Colorectal Cancer Treatments and Studies PI3K/AKT/mTOR signaling in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 13, Issue 5, pp. 1576-1583

DOI: 10.1158/1078-0432.ccr-06-1150

Field-Weighted Citation Impact: 13.38