Improved Therapeutic Effectiveness by Combining Recombinant CXC Chemokine Ligand 10 with Cisplatin in Solid Tumors

200569 citationsJournal Article

Authors

Gang Li · Chongqing Three Gorges Central Hospital

Ling Tian · Sichuan University

Jianmei Hou · Sichuan University

Zhenyu Ding · Sichuan University

Qiuming He · Sichuan University

Ping Feng · Sichuan University

Yanjun Wen · Sichuan University

Abstract

Our data suggest that the combination of CXCL10, a well-tolerated angiogenesis inhibitor, with cisplatin can enhance the antitumor activity. The present findings may be of importance to the further exploration of the potential application of this combined approach in the treatment of lung and colon carcinoma.

Topics & Keywords

Chemokine receptors and signaling Angiogenesis and VEGF in Cancer Proteoglycans and glycosaminoglycans research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 11, Issue 11, pp. 4217-4224

DOI: 10.1158/1078-0432.ccr-04-2117

Field-Weighted Citation Impact: 1.43