Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

2011466 citationsJournal Articlehybrid Open Access

Authors

Sara Brown · Ninewells Hospital

Yuka Asai · McGill University Health Centre

Heather J. Cordell · Newcastle University

Linda Campbell · University of Dundee

Yiwei Zhao · University of Dundee

Haihui Liao · University of Dundee

Kate Northstone ·

Abstract

Filaggrin mutations represent a significant risk factor for IgE-mediated peanut allergy, indicating a role for epithelial barrier dysfunction in the pathogenesis of this disease.

Topics & Keywords

Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization Contact Dermatitis and Allergies

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Journal of Allergy and Clinical Immunology

Volume 127, Issue 3, pp. 661-667

DOI: 10.1016/j.jaci.2011.01.031

Field-Weighted Citation Impact: 22.30