Osteogenesis Associates With Inflammation in Early-Stage Atherosclerosis Evaluated by Molecular Imaging In Vivo

2007685 citationsJournal Articlegreen Open Access

Authors

Elena Aïkawa · Brigham and Women's Hospital

Matthias Nahrendorf · Harvard University

Jose‐Luiz Figueiredo · Brigham and Women's Hospital

Filip K. Świrski · Brigham and Women's Hospital

Timur Shtatland · Brigham and Women's Hospital

Rainer H. Köhler · Harvard University

Farouc A. Jaffer

Abstract

This serial in vivo study demonstrates the real-time association of macrophage burden with osteogenic activity in early-stage atherosclerosis and offers a cellular-resolution tool to identify preclinical microcalcifications.

Topics & Keywords

Bone and Dental Protein Studies Bone Metabolism and Diseases Alkaline Phosphatase Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 116, Issue 24, pp. 2841-2850

DOI: 10.1161/circulationaha.107.732867

Field-Weighted Citation Impact: 13.80