Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data

2001299 citationsReview

Authors

John P. A. Ioannidis · Johns Hopkins University

Philip S. Rosenberg · Bicêtre Hospital

James J. Goedert · Public Health Service of Amsterdam

Lesley J. Ashton · Princess Margaret Hospital for Children

Thomas Benfield · Princess Margaret Hospital for Children

Susan Buchbinder · Johns Hopkins University

R A Coutinho

Abstract

The CCR5-Delta32 and CCR2-64I alleles had a strong protective effect on progression of HIV-1 infection, but SDF-1 3'A homozygosity carried no such protection.

Topics & Keywords

HIV Research and Treatment Immune Cell Function and Interaction HIV/AIDS drug development and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Internal Medicine

Volume 135, Issue 9, pp. 782-795

DOI: 10.7326/0003-4819-135-9-200111060-00008

Field-Weighted Citation Impact: 6.46

Command Palette

Effects of <i>CCR5-Δ 32</i>, <i>CCR2-64I</i>, and <i>SDF-1 3′A</i> Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details