Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

20131,953 citationsJournal Articlebronze Open Access

Authors

Thorsten Klampfl · CeMM Research Center for Molecular Medicine

Heinz Gisslinger · Medical University of Vienna

Ashot S. Harutyunyan · CeMM Research Center for Molecular Medicine

Harini Nivarthi · Austrian Academy of Sciences

Elisa Rumi · Istituti di Ricovero e Cura a Carattere Scientifico

Jelena D. Milosevic Feenstra · CeMM Research Center for Molecular Medicine

Nicole C.C. Them

Abstract

Most patients with essential thrombocythemia or primary myelofibrosis that was not associated with a JAK2 or MPL alteration carried a somatic mutation in CALR. The clinical course in these patients was more indolent than that in patients with the JAK2 V617F mutation. (Funded by the MPN Research Foundation and Associazione Italiana per la Ricerca sul Cancro.).

Topics & Keywords

Myeloproliferative Neoplasms: Diagnosis and Treatment Kruppel-like factors research Chronic Myeloid Leukemia Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 369, Issue 25, pp. 2379-2390

DOI: 10.1056/nejmoa1311347

Field-Weighted Citation Impact: 113.68