Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations

200832 citationsJournal Articlebronze Open Access

Authors

Mária Papp · University of Debrecen

Ildikó Földi · University of Debrecen

Éva Nemes · University of Debrecen

M. Udvardy · University of Debrecen

Jolán Hársfalvi · University of Debrecen

I Altorjay · University of Debrecen

István Máté ·

Abstract

The haptoglobin polymorphism is associated with susceptibility to celiac disease and its clinical presentations. The predominant genotype in the celiac population was Hp2-1, but Hp2-2 predisposed to a more severe clinical course. The phenotype-dependent effect of haptoglobin may result from the molecule's structural and functional properties.

Topics & Keywords

Celiac Disease Research and Management Microbial metabolism and enzyme function Porphyrin Metabolism and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 54, Issue 4, pp. 697-704

DOI: 10.1373/clinchem.2007.098780

Field-Weighted Citation Impact: 1.44