Adrenocortical Zonation in Humans under Normal and Pathological Conditions

2010293 citationsJournal Article

Authors

Koshiro Nishimoto · Keio University Hospital

Ken Nakagawa · Keio University Hospital

Dan Li · Keio University Hospital

Takeo Kosaka · Keio University Hospital

Mototsugu Oya · Keio University Hospital

Shuji Mikami · Keio University Hospital

Hirotaka Shibata ·

Abstract

Immunohistochemistry of the human normal adrenal cortex for CYP11B2 and CYP11B1 revealed a variegated zonation with cell clusters constitutively expressing CYP11B2. This technique may provide a pathological confirmatory diagnosis of adrenocortical adenomas.

Topics & Keywords

Hormonal Regulation and Hypertension Adrenal and Paraganglionic Tumors Adrenal Hormones and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 95, Issue 5, pp. 2296-2305

DOI: 10.1210/jc.2009-2010

Field-Weighted Citation Impact: 7.95