A Randomized Trial of Genotype-Guided Dosing of Warfarin

2013804 citationsJournal Articlebronze Open Access

Authors

Munir Pirmohamed · University of Liverpool

Girvan Burnside · University of Liverpool

Niclas Eriksson · Uppsala University

Andrea Jorgensen · University of Liverpool

Cheng Hock Toh · Newcastle upon Tyne Hospital

Toby Nicholson · Whiston Hospital

Patrick Kesteven ·

Abstract

Pharmacogenetic-based dosing was associated with a higher percentage of time in the therapeutic INR range than was standard dosing during the initiation of warfarin therapy. (Funded by the European Commission Seventh Framework Programme and others; ClinicalTrials.gov number, NCT01119300.).

Topics & Keywords

Pharmacogenetics and Drug Metabolism Health Systems, Economic Evaluations, Quality of Life Atrial Fibrillation Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 369, Issue 24, pp. 2294-2303

DOI: 10.1056/nejmoa1311386

Field-Weighted Citation Impact: 154.24