Insulin Induces Upregulation of Vascular AT<sub>1</sub>Receptor Gene Expression by Posttranscriptional Mechanisms

1998226 citationsJournal Article

Authors

Kerstin Strehlow · University of Cologne

Abstract

Insulin-induced upregulation of the AT1 receptor by posttranscriptional mechanisms may explain the association of hyperinsulinemia with hypertension and arteriosclerosis, because activation of the AT1 receptor plays a key role in the regulation of blood pressure and fluid homeostasis.

Topics & Keywords

Receptor Mechanisms and Signaling Renin-Angiotensin System Studies Neuropeptides and Animal Physiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 98, Issue 22, pp. 2453-2460

DOI: 10.1161/01.cir.98.22.2453

Field-Weighted Citation Impact: 3.26