Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model

2001288 citationsJournal Article

Authors

Hrishikesh Chakraborty · University of North Carolina at Chapel Hill

Pranab K. Sen · University of North Carolina at Chapel Hill

Ronald W. Helms · University of North Carolina at Chapel Hill

Pietro Vernazza · University of North Carolina at Chapel Hill

Susan A. Fiscus · University of North Carolina at Chapel Hill

Joseph J. Eron · University of North Carolina at Chapel Hill

Bruce K. Patterson

Abstract

This model links biological and epidemiological data related to heterosexual HIV-1 transmission. The model can be used to estimate transmission of HIV from men with high semen viral burden from inflammation, or reduced burden after antiretroviral therapy. The results offer a biological explanation for the magnitude of the HIV epidemic in places where earlier studies have shown men have high semen viral burden, such as in sub-Saharan Africa. The model can be used to develop and test HIV-1 prevention strategies.

Topics & Keywords

HIV/AIDS Research and Interventions HIV Research and Treatment Sex work and related issues

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: AIDS

Volume 15, Issue 5, pp. 621-627

DOI: 10.1097/00002030-200103300-00012

Field-Weighted Citation Impact: 10.06