Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis

2009132 citationsJournal Article

Authors

Pedro de Armas · Canary Institute of Cancer Research

David Tejedor · Canary Institute of Cancer Research

Fernando García‐Tellado · Instituto de Productos Naturales y Agrobiología

Abstract

Simple and practical: The asymmetric alkynylation of imines has been revolutionized with two nice examples of a novel model of H-bonding asymmetric metal catalysis with Brønsted acids. The catalytic model comprises two well-differentiated and parallel catalytic cycles: one involving metallic alkynylydes (metal catalysis) and the other one using a chiral Brønsted acid (organocatalysis; see scheme; PG=protecting group).

Topics & Keywords

Asymmetric Synthesis and Catalysis Asymmetric Hydrogenation and Catalysis Catalytic C–H Functionalization Methods

Publication Details

Published in: Angewandte Chemie International Edition

Volume 49, Issue 6, pp. 1013-1016

DOI: 10.1002/anie.200906018

Field-Weighted Citation Impact: 8.14

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Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis

Authors

Abstract

Topics & Keywords

Publication Details