Association of Systemic Lupus Erythematosus With Decreased Immunosuppressive Potential of the IgG Glycome

2015264 citationsJournal Articlehybrid Open Access

Authors

Frano Vučković · Genos (Croatia)

Jasminka Krištić · Science Research Laboratory

Ivan Gudelj · Science Research Laboratory

María Teruel · Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research

Toma Keser · University of Zagreb

Marija Pezer · Science Research Laboratory

Maja Pučić‐Baković

Abstract

The IgG glycome in SLE patients is significantly altered in a way that decreases immunosuppressive action of circulating immunoglobulins. The magnitude of observed changes is associated with the intensity of the disease, indicating that aberrant IgG glycome composition or changes in IgG glycosylation may be an important molecular mechanism in SLE.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Glycosylation and Glycoproteins Research Galectins and Cancer Biology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatology

Volume 67, Issue 11, pp. 2978-2989

DOI: 10.1002/art.39273

Field-Weighted Citation Impact: 17.32