Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

2005133 citationsJournal Articlegold Open Access

Authors

Paige J. Baugher · The University of Texas at Austin

Lakshmi Krishnamoorthy · The University of Texas at Austin

Janet E. Price · The University of Texas MD Anderson Cancer Center

Surangani Dharmawardhane · Central University of the Caribbean

Abstract

This study correlates endogenous Rac activity with high metastatic potential and implicates Rac in the regulation of cell migration and invasion in metastatic breast cancer cells. Taken together, these results suggest a role for both the Rac1 and Rac3 GTPases in human breast cancer progression.

Topics & Keywords

Cellular Mechanics and Interactions Cell Adhesion Molecules Research Protein Kinase Regulation and GTPase Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research

Volume 7, Issue 6, pp. R965-74

DOI: 10.1186/bcr1329

Field-Weighted Citation Impact: 3.01