Attenuated GLP-1 secretion in obesity: cause or consequence?

1996382 citationsJournal Articlebronze Open Access

Authors

L. Ranganath · University of Surrey

J Beety · University of Surrey

LM Morgan · University of Surrey

John W. Wright · University of Surrey

R. J. Howland · University of Surrey

V. Marks · University of Surrey

Abstract

Postprandial GLP-1 secretion in response to oral carbohydrate is considerably attenuated in obese subjects. The cause of this attenuation of GLP-1 secretion is not known although we suggest that both this fall and the overall reduction in GLP-1 values in obese subjects may be related to an increase in plasma non-esterified fatty acids.

Topics & Keywords

Diabetes Treatment and Management Diet and metabolism studies Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 38, Issue 6, pp. 916-919

DOI: 10.1136/gut.38.6.916

Field-Weighted Citation Impact: 3.76