<i>NFKBIA</i> Deletion in Glioblastomas

2010241 citationsJournal Articlebronze Open Access

Authors

Markus Bredel · University Medical Center Freiburg

Denise Scholtens · Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Ajay K. Yadav · Neurological Surgery

Angel A. Alvarez · University of Alabama at Birmingham

Jaclyn J. Renfrow · Robert H. Lurie Comprehensive Cancer Center of Northwestern University

James P. Chandler · Neurological Surgery

Irene L.Y. Yu

Abstract

Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival.

Topics & Keywords

interferon and immune responses Glioma Diagnosis and Treatment Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

No poverty

Publication Details

Published in: New England Journal of Medicine

Volume 364, Issue 7, pp. 627-637

DOI: 10.1056/nejmoa1006312

Field-Weighted Citation Impact: 9.17