Inhibition of Interferon-beta Responses in Multiple Sclerosis Immune Cells Associated With High-Dose Statins

201235 citationsJournal Article

Authors

Xuan Feng · University of Chicago

Diana Han

Abstract

High-dose add-on statin therapy significantly reduces interferon-beta function and type 1 interferon responses in RRMS patients. These data provide a putative mechanism for how statins could counteract the beneficial effects of interferon-beta and worsen disease.

Topics & Keywords

Cytokine Signaling Pathways and Interactions interferon and immune responses Systemic Lupus Erythematosus Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of Neurology

Volume 69, Issue 10, pp. 1303-1303

DOI: 10.1001/archneurol.2012.465

Field-Weighted Citation Impact: 2.27