Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

2013185 citationsJournal Articlebronze Open Access

Authors

Sebastiano Sciarretta

Peiyong Zhai · Rutgers, The State University of New Jersey

Dan Shao · Rutgers, The State University of New Jersey

Daniela Zablocki · Istituto Neurologico Mediterraneo

Narayani Nagarajan · Istituto Neurologico Mediterraneo

Lance S. Terada · The University of Texas Southwestern Medical Center

Massimo Volpe · The University of Texas Southwestern Medical Center

Abstract

Nox4 critically mediates autophagy in response to energy stress in cardiomyocytes by eliciting ROS in the ER and stimulating the protein kinase RNA-activated-like ER kinase signaling pathway.

Topics & Keywords

Autophagy in Disease and Therapy Endoplasmic Reticulum Stress and Disease Sirtuins and Resveratrol in Medicine

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation Research

Volume 113, Issue 11, pp. 1253-1264

DOI: 10.1161/circresaha.113.301787

Field-Weighted Citation Impact: 10.19