Sex modifies the <i>APOE</i>‐related risk of developing Alzheimer disease

2014842 citationsJournal Article

Authors

Victor W. Henderson · Stanford Health Care

Michael D. Greicius · Stanford University

Alzheimer's Disease Neuroimaging Initiative Investigators

Abstract

APOE4 confers greater AD risk in women. Biomarker results suggest that increased APOE-related risk in women may be associated with tau pathology. These findings have important clinical implications and suggest novel research approaches into AD pathogenesis.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Cerebrovascular and genetic disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 75, Issue 4, pp. 563-573

DOI: 10.1002/ana.24135

Field-Weighted Citation Impact: 21.35

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