Limited Geographical Origin and Global Spread of Sulfadoxine-Resistant dhps Alleles in Plasmodium falciparum Populations

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Authors

Toshihiro Mita · Tokyo Women's Medical University

Meera Venkatesan · Howard Hughes Medical Institute

Jun Ohashi · University of Tsukuba

Richard Culleton · Nagasaki University

Nobuyuki Takahashi · Tokyo Women's Medical University

Takahiro Tsukahara · Tokyo Women's Medical University

Mathieu Ndounga

Abstract

The infrequent selection of parasites highly resistant to sulfadoxine and the subsequent migration of resistant lineages from Asia to Africa are similar to the patterns observed in chloroquine and pyrimethamine resistance. These findings strongly suggest that the global migration of resistant parasites has played a decisive role in the establishment of drug-resistant P. falciparum parasites, and that similar patterns may be anticipated for the spread of artemisinin resistance.

Topics & Keywords

Malaria Research and Control Trypanosoma species research and implications HIV/AIDS drug development and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 204, Issue 12, pp. 1980-1988

DOI: 10.1093/infdis/jir664

Field-Weighted Citation Impact: 7.22