Suppression of Rage as a Basis of Simvastatin-Dependent Plaque Stabilization in Type 2 Diabetes

2006157 citationsJournal Articlebronze Open Access

Authors

Chiara Cuccurullo · University of Rome Tor Vergata

Annalisa Iezzi · University of Rome Tor Vergata

Maria Fazia · University of Rome Tor Vergata

Domenico De Cesare · University of Rome Tor Vergata

Andrea Di Francesco · University of Rome Tor Vergata

Raffaella Muraro · University of Rome Tor Vergata

Roberto Bei

Abstract

This study supports the hypothesis that simvastatin inhibits plaque RAGE expression by decreasing MPO-dependent AGE generation. This effect in turn might contribute to plaque stabilization by inhibiting the biosynthesis of PGE2-dependent MMPs, responsible for plaque rupture.

Topics & Keywords

Advanced Glycation End Products research Lipoproteins and Cardiovascular Health Antiplatelet Therapy and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 26, Issue 12, pp. 2716-2723

DOI: 10.1161/01.atv.0000249630.02085.12

Field-Weighted Citation Impact: 7.14