Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study

201177 citationsJournal Articlehybrid Open Access

Authors

Tony Antoniou · St Michael's Hospital

Tara Gomes · Institute for Clinical Evaluative Sciences

Muhammad Mamdani · University of Toronto

Zhan Yao · Institute for Clinical Evaluative Sciences

Chelsea Hellings · Institute for Clinical Evaluative Sciences

Amit X. Garg · Western University

Matthew A. Weir

Abstract

Among older patients receiving spironolactone, treatment with trimethoprim-sulfamethoxazole was associated with a major increase in the risk of admission to hospital for hyperkalaemia. This drug combination should be avoided when possible.

Topics & Keywords

Potassium and Related Disorders Pneumocystis jirovecii pneumonia detection and treatment Pharmacological Effects and Toxicity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMJ

Volume 343, Issue sep12 1, pp. d5228-d5228

DOI: 10.1136/bmj.d5228

Field-Weighted Citation Impact: 4.72