Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

2015506 citationsJournal Article

Authors

Alexander Kapustin · University College London

Martijn Chatrou · King's College London

Ignat Drozdov · King's College London

Ying Zheng · University College London

Sean M. Davidson · Great Ormond Street Hospital

Daniel Soong · Great Ormond Street Hospital

Malgorzata Furmanik ·

Abstract

This study identifies MVs as exosomes and shows that factors that can increase exosome release can promote vascular calcification in response to environmental calcium stress. Modulation of the exosome release pathway may be as a novel therapeutic target for prevention.

Topics & Keywords

Dermatological and Skeletal Disorders Parathyroid Disorders and Treatments Connective tissue disorders research

Publication Details

Published in: Circulation Research

Volume 116, Issue 8, pp. 1312-1323

DOI: 10.1161/circresaha.116.305012

Field-Weighted Citation Impact: 34.09

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Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

Authors

Abstract

Topics & Keywords

Publication Details