Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

2010185 citationsJournal Articlebronze Open Access

Authors

Xiaoxin X. Wang · University of Colorado Denver

Tao Jiang · University of Colorado Denver

Yan Shen · Denver VA Medical Center

Yupanqui Caldas · University of Colorado Denver

Shinobu Miyazaki‐Anzai · University of Colorado Denver

Hannah Santamaria · Denver VA Medical Center

Cydney Urbanek

Abstract

Our findings indicate a critical role for FXR in the development of diabetic nephropathy and show that FXR activation prevents nephropathy in type 1 diabetes.

Topics & Keywords

Drug Transport and Resistance Mechanisms Liver Disease Diagnosis and Treatment Cholesterol and Lipid Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 59, Issue 11, pp. 2916-2927

DOI: 10.2337/db10-0019

Field-Weighted Citation Impact: 5.15