Enhanced Ca <sup>2+</sup> -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension

2012124 citationsJournal Articlebronze Open Access

Authors

Aya Yamamura · First Affiliated Hospital of Soochow University

Qiang Guo · Nagoya City University

Hisao Yamamura · Soochow University

Adriana M. Zimnicka · Kinjo Gakuin University

Nicole M. Pohl · Nagoya City University

Kimberly A. Smith · Kinjo Gakuin University

Ruby A. Fernandez ·

Abstract

The extracellular Ca(2+)-induced increase in [Ca(2+)](cyt) due to upregulated CaSR is a novel pathogenic mechanism contributing to the augmented Ca(2+) influx and excessive PASMC proliferation in patients and animals with pulmonary arterial hypertension.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Magnesium in Health and Disease Ion Transport and Channel Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 111, Issue 4, pp. 469-481

DOI: 10.1161/circresaha.112.266361

Field-Weighted Citation Impact: 5.48