High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i> –Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk

2006640 citationsJournal Article

Authors

Takao Maekita · Wakayama Medical University

Kazuyuki Nakazawa · Wakayama Medical University

Mami Mihara

Takeshi Nakajima · National Cancer Center Hospital East

Kimihiko Yanaoka · Wakayama Medical University

Mikitaka Iguchi · Wakayama Medical University

Kenji Arii · Wakayama Medical University

Abstract

It was indicated that H. pylori infection potently induces methylation of CGIs to various degrees. Methylation levels of specific CGIs seemed to reflect gastric cancer risk in H. pylori-negative individuals.

Topics & Keywords

Helicobacter pylori-related gastroenterology studies Gastric Cancer Management and Outcomes Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 12, Issue 3, pp. 989-995

DOI: 10.1158/1078-0432.ccr-05-2096

Field-Weighted Citation Impact: 33.40