Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair–Deficient Colorectal Tumors

2007172 citationsJournal Articlebronze Open Access

Authors

Rosa M. Xicola · Universitat de Barcelona

Xavier Llor · Hospital Universitario de Guadalajara

Elisenda Pons · Hospital Universitario de Guadalajara

Antoni Castells · Universitat Autònoma de Barcelona

Cristina Alenda · Hospital Universitario de Guadalajara

Virgı́nia Piñol · Hospital Universitario de Canarias

Montserrat Andreu

Abstract

The pentaplex panel of mononucleotide repeats performs better than the NCI panel for the detection of mismatch repair-deficient tumors. Simultaneous assessment of the instability of BAT26 and NR24 is as effective as use of the pentaplex panel for diagnosing mismatch repair deficiency.

Topics & Keywords

Genetic factors in colorectal cancer Cancer Genomics and Diagnostics DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 99, Issue 3, pp. 244-252

DOI: 10.1093/jnci/djk033

Field-Weighted Citation Impact: 7.83