Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis

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Authors

Ragini Vittal · Indiana University School of Medicine

Elizabeth A. Mickler · Indiana University – Purdue University Indianapolis

Amanda Fisher · Indiana University – Purdue University Indianapolis

Chen Zhang · Indiana University School of Medicine

Katia Rothhaar · ImmuneWorks (United States)

Hongmei Gu · Indiana University – Purdue University Indianapolis

Krista Brown

Abstract

Anti-col(V) immunity is pathogenic in IPF, and col(V)-induced tolerance abrogates bleomycin-induced fibrogenesis and down regulates TGF- β-related signaling pathways.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Occupational exposure and asthma Inhalation and Respiratory Drug Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 10, pp. e76451-e76451

DOI: 10.1371/journal.pone.0076451

Field-Weighted Citation Impact: 5.69