Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

2012473 citationsJournal Articlebronze Open Access

Authors

Marcos de Lima · The University of Texas MD Anderson Cancer Center

Ian McNiece · The University of Texas MD Anderson Cancer Center

Simon N. Robinson · The University of Texas MD Anderson Cancer Center

Mark F. Munsell · The University of Texas MD Anderson Cancer Center

Mary Eapen · Medical College of Wisconsin

Mary M. Horowitz · Medical College of Wisconsin

Amin M. Alousi

Abstract

Poor engraftment due to low cell doses restricts the usefulness of umbilical-cord-blood transplantation. We hypothesized that engraftment would be improved by transplanting cord blood that was expanded ex vivo with mesenchymal stromal cells.

Topics & Keywords

Mesenchymal stem cell research Hematopoietic Stem Cell Transplantation Pluripotent Stem Cells Research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 24, pp. 2305-2315

DOI: 10.1056/nejmoa1207285

Field-Weighted Citation Impact: 24.10