Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

2013300 citationsJournal Articlebronze Open Access

Authors

Nazha Hamdani · Universidade do Porto

Constantijn Franssen · Ruhr University Bochum

André P. Lourenço · Universidad de Navarra

Inês Falcão‐Pires · Universidad de Navarra

Dulce Fontoura · Universidade do Porto

Sara Leite · Universidade do Porto

Luisa Plettig ·

Abstract

Obese ZSF1 rats developed heart failure with preserved ejection fraction during a 20-week time span. Titin hypophosphorylation importantly contributed to the underlying myocardial DD.

Topics & Keywords

Cardiovascular Function and Risk Factors Cardiac Structural Anomalies and Repair Cardiomyopathy and Myosin Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Heart Failure

Volume 6, Issue 6, pp. 1239-1249

DOI: 10.1161/circheartfailure.113.000539

Field-Weighted Citation Impact: 11.51