Gait speed in Parkinson disease correlates with cholinergic degeneration

2013219 citationsJournal Article

Authors

Nicolaas I. Bohnen · VA Ann Arbor Healthcare System

Kirk A. Frey

Stephanie A. Studenski · Geriatric Research Education and Clinical Center

Vikas Kotagal · Geriatric Research Education and Clinical Center

Robert A. Koeppe · VA Ann Arbor Healthcare System

Peter J. H. Scott · Geriatric Research Education and Clinical Center

Roger L. Albin · Geriatric Research Education and Clinical Center

Abstract

Comorbid cortical cholinergic denervation is a more robust marker of slowing of gait in PD than nigrostriatal denervation alone. Gait speed is not significantly slower than normal in subjects with PD with relatively isolated nigrostriatal denervation.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Balance, Gait, and Falls Prevention

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 81, Issue 18, pp. 1611-1616

DOI: 10.1212/wnl.0b013e3182a9f558

Field-Weighted Citation Impact: 11.03