Type 1 Helper T Cells and FoxP3-positive T Cells in HIV–Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

2008139 citationsJournal Articlegreen Open Access

Authors

Graeme Meintjes · University of Cape Town

Katalin A. Wilkinson · South African Medical Research Council

Molebogeng X. Rangaka · University of Cape Town

Keira Skolimowska · GF Jooste Hospital

K van Veen · University of Cape Town

Musaed Abrahams · Western Cape Department of Health

Ronnett Seldon

Abstract

There is an association between helper T-cell type 1 expansions and TB-IRIS, but the occurrence of similar expansions in non-IRIS brings into question whether these are causal. The defect in immune regulation responsible for TB-IRIS remains to be fully elucidated.

Topics & Keywords

Infectious Diseases and Tuberculosis Orthopedic Infections and Treatments Tuberculosis Research and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 178, Issue 10, pp. 1083-1089

DOI: 10.1164/rccm.200806-858oc

Field-Weighted Citation Impact: 11.35