Cytarabine Dose for Acute Myeloid Leukemia

2011405 citationsJournal Articlebronze Open Access

Authors

Bob Löwenberg · Erasmus MC

Thomas Pabst · University Hospital of Bern

Edo Vellenga · University Medical Center Groningen

Wim van Putten · Erasmus MC

Harry C. Schouten · University Medical Center

Carlos Graux · Institut du Savoir Montfort

Augustin Ferrant ·

Abstract

Induction therapy with cytarabine at the lower dose already produced maximal antileukemic effects for all response end points, suggesting a plateau in the dose-response relationship above this dose level. High-dose cytarabine results in excessive toxic effects without therapeutic benefit. (Netherlands Trial Register number, NTR230.).

Topics & Keywords

Acute Myeloid Leukemia Research Acute Lymphoblastic Leukemia research Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 364, Issue 11, pp. 1027-1036

DOI: 10.1056/nejmoa1010222

Field-Weighted Citation Impact: 18.39